Gregor Mendel Professor of Genetics and of Medicine
A major area of our interest is how eukaryotic cells sense and respond to stress in the form of damage to their genetic material. When cells incur DNA...
Our laboratory is studying the regulation, mechanisms, and physiological importance of protein breakdown in animal cells. We are presently attempting to...
Our lab focuses on the molecular nature of innate immune interactions between microbial pathogens and the host. Pathogenic bacteria have evolved complex...
Bacterial pathogens that grow within human cells are responsible for multiple diseases and millions of deaths worldwide. The primary goal of our research...
The increasing emergence of bacterial strains resistant to antibiotics is far outpacing our ability to develop novel therapies to treat these infections....
The overarching goal of the Jost lab is to define the molecular mechanisms of host-microbiome communication using a combination of systematic CRISPR...
Ancient signaling pathways lie at the base of the initiation of immunity, serving to transmit signals from Pattern Recognition Receptors (PRRs) to trigger...
William Ellery Channing Professor of Medicine and Professor of Immunology
My laboratory has long been interested in the interactions of microbes, both commensals and pathogens, with the immune system. Our overall major research...
Our research focuses on the processes that mediate and regulate the movement of membrane proteins throughout cells. In particular our studies have help...
My lab studies the interplay between the gut microbiome and the immune system and how their “miscues” can lead to autoimmune diseases, particularly type 1...
The Lieberman laboratory studies the innate and adaptive immune response to infection and cancer. They seek to understand how cytotoxic T lymphocytes and...
The Mekalanos laboratory is engaged in the analysis of bacterial virulence and functional genomics. The goal of these studies is to understand how pathogenic... Read more about John Joseph Mekalanos
We are interested in mechanisms whereby bacterial pathogens cause disease and in defining and testing immune protective mechanisms relevant to prevention...
Despite the growing recognition of the importance of the microbiota to humans, there are fundamental aspects of the microbiota and its relation to the...
Research in the Serhan laboratory focuses on structural elucidation of bioactive small molecules that activate the resolution of acute inflammation. Our... Read more about Charles N. Serhan
Research in our lab uses a combination of cellular and molecular approaches in the analysis of T-cell responses to bacterial pathogens. Many virulence...
We are exploring pathogen-host interactions, particularly in the context of animal models relevant to human infection of clinically important enteric...
