Ancient signaling pathways lie at the base of the initiation of immunity, serving to transmit signals from Pattern Recognition Receptors (PRRs) to trigger...
Professor of Biological Chemistry and Molecular Pharmacology
For many years our research group has been interested in the molecular mechanisms of various antibiotics and the fundamental cellular processes they inhibit.... Read more about Daniel Kahne
William Ellery Channing Professor of Medicine and Professor of Immunology
My laboratory has long been interested in the interactions of microbes, both commensals and pathogens, with the immune system. Our overall major research...
Assistant Professor of Biological Chemistry and Molecular Pharmacology
Research in our lab takes a bottom-up approach to tackling molecular challenges in cancer biology. Basic chemical research – development of new reactions,... Read more about Justin Kim
Our research focuses on the processes that mediate and regulate the movement of membrane proteins throughout cells. In particular our studies have help...
The ability to precisely and permanently alter DNA sequences in living cells has been dramatically simplified by the adaptation of a prokaryotic immune...
My lab studies the interplay between the gut microbiome and the immune system and how their “miscues” can lead to autoimmune diseases, particularly type 1...
Electron cryo-microscopy (cryo-EM) is a rapidly advancing research area, powered by the knowledge of biology, physics, material science and computation. Single... Read more about Maofu Liao
The Lieberman laboratory studies the innate and adaptive immune response to infection and cancer. They seek to understand how cytotoxic T lymphocytes and...
The research efforts in the laboratory are directed towards understanding the molecular basis of pathogenesis of human infections caused by opportunistic...
The Mekalanos laboratory is engaged in the analysis of bacterial virulence and functional genomics. The goal of these studies is to understand how pathogenic... Read more about John Joseph Mekalanos
My lab is interested in the structure, dynamics, and function of the cytoskeleton. We use imaging-based assays in living cells and in vitro extracts, in... Read more about Timothy J. Mitchison
in situ single-cell transcriptomic techniques offer the exciting ability to characterize gene expression within single cells in their native tissue context.... Read more about Jeffrey Moffitt
We are interested in mechanisms whereby bacterial pathogens cause disease and in defining and testing immune protective mechanisms relevant to prevention...
Despite the growing recognition of the importance of the microbiota to humans, there are fundamental aspects of the microbiota and its relation to the...
We are interested in the molecular mechanisms by which proteins are transported across the endoplasmic reticulum (ER) membrane. Proteins are transported...
Professor of Biological Chemistry and Molecular Pharmacology
Research in the Roberts laboratory is centered on kinases, kinase inhibitors, and cancer. We work in a variety of model systems and utilize approaches varying... Read more about Thomas McCoy Roberts
Irene Heinz Given Professor of Immunology and Infectious Diseases
Despite years of research, tuberculosis remains a leading killer, causing almost two million deaths each year worldwide. While the treatment for drug-...
