Diverse control mechanisms converge to ensure that gene transcripts are expressed and processed accurately. Dissection of these interactions has proven...
The focus of my laboratory is to elucidate how deregulated cell signaling drives cancer. To achieve this we have been taking a multi-faceted approach;...
The D'Amore laboratory has a long-standing interest in the regulation of vascular development and pathology. One major area has involved investigating the role... Read more about Patricia Ann D'Amore
Alvan T. and Viola D. Fuller American Cancer Society Professor of Radiation Oncology
Our laboratory examines the molecular signaling pathways which regulate the DNA damage response in mammalian cells. Disruption of these pathways, by...
Dean of the Faculty of Medicine Caroline Shields Walker Professor of Medicine
Our lab focuses on stem cell biology, with an emphasis on somatic cell reprogramming, hematopoietic differentiation from human and mouse pluripotent stem...
Associate Professor in the Department of Molecular Metabolism
Our lab investigates the metabolic mechanisms that regulate cellular and organismal adaptation to physiologic and pathologic stress conditions. Within...
The goal of my lab is to understand the regulatory relationship between cellular signaling pathways and metabolic pathways. We are particularly interested in... Read more about Christian Dibble
Gregor Mendel Professor of Genetics and of Medicine
A major area of our interest is how eukaryotic cells sense and respond to stress in the form of damage to their genetic material. When cells incur DNA...
The Farnung Lab aims to answer key mechanistic questions at the intersection of chromatin and transcription. We employ biochemical, biophysical, and structural... Read more about Lucas Farnung
The molecular mechanisms underlying neurodegeneration in human disorders like Alzheimer's disease and Parkinson's disease remain mysterious, in part...
Associate Professor of Biological Chemistry and Molecular Pharmacology
The Ubiquitin Proteasome System (UPS) is involved in virtually any cellular process and frequently implicated in human pathologies. Ubiquitin, through the...
Our group studies cell death/proliferation signals in relation to development and disease, particularly in skin cancer. We attempt to understand critical...
Our broad interest is to understand how cell-cell signaling molecules set up spatial pattern, particularly in the formation of neuronal connections. We...
Assistant Professor of Stem Cell and Regenerative Biology
Cells of the immune system defend us against a variety of insults, including infection by pathogens. However, it is now clear that immune cells also have... Read more about Ruth A. Franklin
Our laboratory is using cellular, molecular, bioengineering, and computational biology tools to understand how mechanical forces generated by the flow of...