Although numerous eukaryotic genomes have been sequenced, much still remains to be understood about how the genes in those genomes are regulated. The...
Professor of Biological Chemistry and Molecular Pharmacology
Our lab studies eukaryotic gene expression. We are concentrating on three areas: (A) the functions and interactions of the RNA polymerase II (RNApII)...
Diverse control mechanisms converge to ensure that gene transcripts are expressed and processed accurately. Dissection of these interactions has proven...
Gregor Mendel Professor of Genetics and of Medicine
A major area of our interest is how eukaryotic cells sense and respond to stress in the form of damage to their genetic material. When cells incur DNA...
Mice live 3 years, dogs 15 years and humans 100 years. How does Nature change the lifespan of species? We are trying to uncover the molecular basis for...
Neurodegenerative diseases like Alzheimer’s and Parkinson’s disease are diseases caused when proteins abnormally fold and aggregate in specific cell types of... Read more about Vikram Khurana
The Mekalanos laboratory is engaged in the analysis of bacterial virulence and functional genomics. The goal of these studies is to understand how pathogenic... Read more about John Joseph Mekalanos
We are interested in epigenetic mechanisms that control cellular memory and genome stability in eukaryotes and use yeast and mammalian cells as model...
The vertebrate immune system is capable of specifically recognizing and responding to an enormous number of antigens. The interaction with antigen is...
Our laboratory aims to understand normal cell division mechanisms and to discover cell division defects that are unique to cancer cells. We take a range...
Elliott T. and Onie H. Adams Professor of Biochemistry and Systems Biology
What can we build with biology? We use a synthetic biology approach to understanding biological systems through design, making new biological structures...
My research focuses on understanding the relationship between genotype and phenotype, with a special interest in how biochemistry, molecular design, and...
David Wesley Gaiser Professor of Biological Chemistry and Molecular Pharmacology
Transcriptional regulation in response to environmental and developmental cues is mediated by the combinatorial and synergistic action of specific DNA-...
Within cells macromolecules form complex intertwined networks of functionally interacting components. The molecular mechanisms underlying biological...
A critical step in eukaryotic gene regulation is the control of transcription across the chromatin template. While transcription has been extensively...
Professor of Biological Chemistry and Molecular Pharmacology
We are interested in how kinases in general, and phosphatidylinositol 3-kinases (PI3K) in particular, control malignant transformation. The work of our...
