Bert and Natalie Vallee Professor of Molecular Pathology
Ubiquitin and ubiquitin-like (UBL) protein conjugation systems control a vast array of cellular processes, and impact virtually every biological system....
The focus of this laboratory is to understand the genetic basis of development of form – that is shape, size and proportion during vertebrate development...
We are interested in the signaling mechanisms by the Wnt family of secreted molecules. It has become clear that Wnt proteins are one of about half a dozen...
* Salmonella persisters and their translational program during infection:We recently found out that Salmonella persisters that are multidrug tolerant bacteria... Read more about Sophie Helaine
My laboratory is focused on two tumor suppressor gene diseases associated with renal tumorigenesis and hamartomas: tuberous sclerosis complex (TSC) and...
Bacterial pathogens that grow within human cells are responsible for multiple diseases and millions of deaths worldwide. The primary goal of our research...
Our lab tries to understand the molecular mechanisms underlying pluripotency and nuclear reprogramming. Pluripotency denotes the ability of cells, such as...
Skin, the largest organ we have, protects us from insults and dehydration, and facilitates sensory perception and thermoregulation. These multifaceted...
The increasing emergence of bacterial strains resistant to antibiotics is far outpacing our ability to develop novel therapies to treat these infections....
Director, Wyss Institute for Biologically Inspired Engineering
My laboratory is interested in how microenvironmental cues, particularly mechanical forces and extracellular matrix, regulate tissue development, physiology... Read more about Donald Elliot Ingber
Current therapies for pediatric osteoporosis, regardless of cause, are limited. There are no therapies to prevent fractures; nor do we have any way to...
A. Werk Cook Professor of Radiation Oncology (Tumor Biology)
The overall goal of our research is to understand the role of the tumor microenvironment, including the tumor vasculature and matrix, in tumor growth and...
The focus of my research is to understand mechanisms of sensitivity and resistance to kinase inhibitors and to translate laboratory based observations...
Associate Professor, Department of Pediatric Oncology
Our laboratory research program is centered in understanding the structure and function of ATP-dependent chromatin remodeling complexes, with emphasis on...
Dr. Kaelin's research seeks to understand how, mechanistically, mutations affecting specific genes cause cancer, with a particular focus on particular tumor... Read more about William Kaelin
Ancient signaling pathways lie at the base of the initiation of immunity, serving to transmit signals from Pattern Recognition Receptors (PRRs) to trigger...
