We use methods in molecular biology, immunology, and structural biology to study host-pathogen interactions, with the goal of informing strategies aimed...
Professor of Biological Chemistry and Molecular Pharmacology
The Adelman lab aims to elucidate how cells react in a rapid yet balanced manner to external signals, at the transcriptional and epigenetic level. We use...
The broad focus of the Alt lab is the elucidation of mechanisms that generate antigen receptor diversity in the Immune system and mechanisms that maintain... Read more about Frederick W. Alt
We are a collaborative group of genome editing scientists at the Translational Neuroscience Center of Boston Children’s Hospital and Harvard Medical...
There is now overwhelming evidence indicating that VEGF, TGFβ, PDGF, and Notch among others, the molecules that are essential for vascular formation, are...
Associate Professor of Biological Chemistry and Molecular Pharmacology
Protein-Protein Interactions (PPIs) is the Holy Grail of therapeutic intervention, offering a plethora of distinct structural landscapes that can be targeted... Read more about Haribabu Arthanari
Cancer cells display remarkable plasticity allowing them to adapt to ever changing environments. A key feature of this plasticity is their ability to...
Bacterial cells come in a wide variety of shapes and sizes. Within a given class, however, cells typically grow and divide in such a way as to maintain...
My laboratory is focused on endothelial cells and how they become disrupted in disease. We also study a normal, yet highly proliferative endothelial cell...
Gustavus Adolphus Pfeiffer Professor of Biological Chemistry and Molecular Pharmacology
The long-term goal of our research program is to understand the molecular logic of signal transduction, focusing on proteins implicated in human disease. The... Read more about Stephen Charles Blacklow
My lab studies how organisms defend against environmental and metabolic stresses, and how these stress defenses influence aging. Most of our work involves...
Associate Professor of Biological Chemistry and Molecular Pharmacology
We are interested in understanding transport mechanisms in the cell. In particular, we are interested in how molecules are transported into, out of, and...
We are interested in elucidating the cellular processes and pathways that are involved in the initiation and progression of epithelial tumors. Currently...
Associate Professor of Biological Chemistry and Molecular Pharmacology
Dysregulation of protein homeostasis drives many types of cancer, infection and neurodegeneration. The ubiquitin system performs a central role in maintenance... Read more about Sara Buhrlage
Professor of Biological Chemistry and Molecular Pharmacology
Our lab studies eukaryotic gene expression. We are concentrating on three areas: (A) the functions and interactions of the RNA polymerase II (RNApII)...