Evan D. Rosen

Evan D. Rosen

Professor of Medicine
Evan D. Rosen
My laboratory studies the biology of the adipocyte, with specific emphasis on deciphering the transcriptional pathways that promote adipogenesis and regulate metabolism in the mature fat cell. We use biased and unbiased approaches to discover novel pathways regulating differentiation, insulin sensitivity, and lipid handling. We then study these factors and pathways in vitro and in vivo. We have also become interested in epigenetic events in adipocytes, and we have used altered chromatin modifications in developing fat cells to identify new transcriptional pathways involving COUP-TFs, interferon regulatory factors, and others. We are using whole genome epigenetic approaches to study metabolic events outside of differentiation as well, including insulin resistance. Finally, we are studying the mechanisms by which human Type 2 diabetes genes affect the risk of the disease, by using integrated genetic, genomic, biochemical, and physiological approaches.

Contact Information

Beth Israel Deaconess Medical Center
Center for Life Science, Rm. 743
Three Blackfan Circle
Boston, MA 02115
p: 617-735-3221