Jon Christopher Aster

Jon Christopher Aster

Professor of Pathology
Jon Christopher Aster
The Aster laboratory primarily studies Notch signaling in cancer. Ongoing projects seek to understand through use of ChIP-Seq and other comprehensive genome-wide approaches how Notch regulates the genomes of leukemia cells; how Notch activity is coordinated at the level of the genome with other transcription factors involved in T cell development and T cell transformation, as well as the components of the basal transcriptional machinery and regulators of histone marks; how post-translational modifications regulate Notch; and how Notch effects on leukemia cells are modified by interactions with bone marrow stromal cells. These studies are being conducted within the context of several multi-investigator projects, which foster close collaborations with investigators using structural, chemical, bioinformatic, and animal modeling approaches to study physiologic and pathophysiologic Notch signaling.

Contact Information

Brigham and Women's Hospital
NRB Building, Room 652E
77 Avenue Louis Pasteur
Boston, MA 02115
p: 617-525-4370

Community or Program Affiliation