#  Jonathan Strecker 

Assistant Professor of Genetics

 

 

 



   ![strecker_jonathan.jpg](/sites/g/files/omnuum5321/files/styles/hwp_4_5__480x600/public/bbsphd/files/strecker_jonathan.jpg?itok=zqqvxBhj) 

 



 

 location\_on Massachusetts General HospitalDepartment of Molecular Biology, Room 7300185 Cambridge StreetBoston, MA 02114 

 email <strecker@molbio.mgh.harvard.edu> 

 laptop\_windows [Lab Website](https://www.thestreckerlab.org/) 

 laptop\_windows [Publications](https://pubmed.ncbi.nlm.nih.gov/?term=Jonathan+Strecker) 

 

 



 

Our lab is broadly interested in the biology of immune proteins found throughout nature. Bacteria have evolved numerous defenses against phage, including CRISPR-Cas systems, and while these predominantly function as RNA-guided nucleases, additional functions exist including CRISPR-associated transposases that perform RNA-targeted DNA insertion, and CRISPR-associated proteases that cleave protein substrates upon RNA detection.

We are interested in how cells sense and respond to nucleic acids and how diverse enzymes can be controlled in a programmable manner. Our long-term goal is to use these basic discoveries to enable new functions in biology and to contribute to our understanding of the human genome.



 

 

 





 

 

- ## Program Affiliation
    
     [Genetics](/bbs-faculty/genetics)
- ## Discipline
    
     [Biochemistry](/discipline/biochemistry) [Genetics](/discipline/genetics) [Microbiology](/discipline/microbiology) [Molecular Biology](/discipline/molecular-biology) [Technology Development](/discipline/technology-development)
- ## Organism
    
     [Model Bacteria](/organism/model-bacteria) [Human](/organism/human)
- ## People
    
     [Faculty](/people/faculty)
- ## Location
    
     [Massachusetts General Hospital](/location/massachusetts-general-hospital)