Although numerous eukaryotic genomes have been sequenced, much still remains to be understood about how the genes in those genomes are regulated. The...
Professor of Biological Chemistry and Molecular Pharmacology
Our lab studies eukaryotic gene expression. We are concentrating on three areas: (A) the functions and interactions of the RNA polymerase II (RNApII)...
Our research focuses on new technologies for genomic & proteomic measurement, synthesis and modeling of biomedical & ecological systems -- in... Read more about George Mcdonald Church
Diverse control mechanisms converge to ensure that gene transcripts are expressed and processed accurately. Dissection of these interactions has proven...
Alvan T. and Viola D. Fuller American Cancer Society Professor of Radiation Oncology
Our laboratory examines the molecular signaling pathways which regulate the DNA damage response in mammalian cells. Disruption of these pathways, by...
Gregor Mendel Professor of Genetics and of Medicine
A major area of our interest is how eukaryotic cells sense and respond to stress in the form of damage to their genetic material. When cells incur DNA...
The Farnung Lab aims to answer key mechanistic questions at the intersection of chromatin and transcription. We employ biochemical, biophysical, and structural... Read more about Lucas Farnung
Taekjip Ha analyzes single molecules to understand how they act in complex biological systems. Ha and his team combine sophisticated biophysical manipulation... Read more about Taekjip Ha
A basic problem in biology concerns how cells destroy their own proteins. The elimination of misfolded, and therefore potentially toxic, proteins is...
Bert and Natalie Vallee Professor of Molecular Pathology
Ubiquitin and ubiquitin-like (UBL) protein conjugation systems control a vast array of cellular processes, and impact virtually every biological system....