# Rajat Gupta Associate Professor ![Gupta](/sites/g/files/omnuum5321/files/styles/hwp_4_5__320x400/public/2025-06/Gupta%20Photo.jpg?itok=TKafFU3G) email laptop\_windows [Publications](https://www.ncbi.nlm.nih.gov/myncbi/rajat.gupta.1/bibliography/public/) Brigham and Women's Hospital Genetics and Cardiovascular Medicine, NRB 160B 77 Avenue Louis Pasteur Boston, MA 02115 The Gupta Lab studies the gene regulatory networks that cause vascular disease using high-throughput CRISPR screens. We have expanded Perturb-seq methods to cover all 20,000 genes and identified co-regulated gene networks using AI/ML methods. For coronary artery disease we identified a novel collection of variants that regulate endothelial cell shear stress response (Schnitzler, et al. Nature 2024). Surprisingly the genes in this pathway are also associated with increased risk of a rare neurovascular disease-Cerebral Cavernous Malformations. We are studying how these variants affect cellular function in different cell types and stages of development. Additionally, we are using new types of genome-wide CRISPR screens to discover the risk pathways for multiple cardiometabolic traits in other vascular cells, immune cells, and hepatocytes. - ## Program Affiliation [Genetics](/bbs-faculty/genetics) - ## People [Faculty](/people/faculty) - ## Location [Brigham and Women's Hospital](/location/brigham-and-womens-hospital)