The Xavier Laboratory, spanning the Department of Molecular Biology at Massachusetts General Hospital and the Broad Institute, focuses on systematic characterization of genetic variants to understand the regulation of innate and adaptive immunity; initiation and resolution of tissue inflammation using single-cell and spatial transcriptomics; chemical biology to control and correct cellular disease phenotypes suggested by human genetics; molecular mechanisms that determine the roles of microbes in health and disease; and development of computational approaches to uncover patterns of human and microbial pathway activation during disease and treatment.

EXPERIMENTAL APPROACH –

- Spatial transcriptomics
- Development of new technologies to study the immune system
- CRISPR base-editing and genetic screens
- Lysosomal biology
- Microbiome mining
- Computational methods

FIELD OF STUDY –

- Autoimmunity
- Genotype-to-phenotype maps
- Gut microbiome function
- Deep mechanistic studies to chemical biology
- Mucosal immunity
- Tissue metabolism