Yu-Hua Tseng

Yu-Hua Tseng

Professor of Medicine
Yu-Hua Tseng
Obesity is an epidemic health problem worldwide and is a significant risk factor for many human diseases, including diabetes, dyslipidemias, non-alcoholic fatty liver, gallstones, cardiovascular disease, Alzheimer's disease and even some cancers. Obesity develops when energy intake exceed energy expenditure. Despite this simple nature, the maintenance of energy balance is complex. We are particularly intrigued by the unique nature of the energy-burning brown fat. The current research projects in our lab focus on the following specific areas: (1) Role of developmental signals in the determination of brown versus white adipose cell fate; (2) Identification and characterization of progenitor/stem cells that give rise to different adipose depots in rodents and humans; (3) Contribution and importance of fuel utilization for the energy-expending process of brown fat; and (4) Integration of central and peripheral controls on whole body energy homeostasis. Our laboratory has taken a broad-based approach to understand the mechanisms that underlie these processes, including cellular and molecular analysis, transgenic models, in vitro and in vivo imaging and '-omic'.profiling. Ultimately, we hope the combined knowledge from these projects will allow us to integrate central and peripheral controls of energy homeostasis and aid in identifying specific new therapeutic targets to aid in the fight against obesity, diabetes and related diseases.

Contact Information

Joslin Diabetes Center
One Joslin Place
Boston, MA 02215
p: 617-309-1967

Community or Program Affiliation

Organism

People