Our research focuses on how stem cell and progenitor populations in developing organs are regulated by signaling networks. Important areas of study include how transcription factors and chromatin modification proteins are involved in organ development. We also study how signaling networks important in developing organs are co-opted in disease.

We have taken a genome-wide approach to identifying targets of the Wilms' tumor-1 transcription factor (WT1) using chromatin immunoprecipitation, from embryonic and mature kidneys. These studies have identified WT1 as a master regulator of a network of gene expression in the kidney, regulating the expression of other transcription factors important in the developing and adult kidney. In a highly differentiated cell known as the podocyte, WT1 regulates the expression of genes vital to carrying out filtration of the blood to preserve homeostasis. Current studies are aimed at understanding how WT1 regulation of gene expression changes in podocyte injury states that lead to chronic kidney disease.

Our studies on organ development are being extended to several disease models. Polycystic Kidney Disease (PKD) is one of the most common genetic diseases. We are investigating roles for integrins and receptor tyrosine kinases in the pathogenesis of PKD. These studies have identified a role for Wnt signaling in PKD that we are continuing to investigate.

We have also begun to investigate the molecular basis for common urological malformations that lead to kidney failure.