Small cell lung cancer (SCLC) is a highly aggressive and treatment-resistant malignancy with limited therapeutic options. This challenge stems in part from the near-universal loss-of-function (LOF) mutations in key tumor suppressor genes such as RB1 and...
The Insco Lab investigates how aberrant RNA and defects in nuclear RNA surveillance drive oncogenesis, with an emphasis on melanoma. We use zebrafish models, patient datasets, and mechanistic assays in human melanoma cell lines to define clinically...
Chronic pain and headache disorders are two leading causes of disability world-wide. Improving treatments for these conditions is a major focus of my lab as well as my clinical practice as a neurologist. The experience of pain begins with specialized...
The Horlbeck lab studies Chromatinopathies, a large class of genetic disorders in which disruption of chromatin modifying machinery leads to developmental delay and intellectual disability. The lab seeks to understand how chromatin regulation shapes cell...
The Abudayyeh-Gootenberg lab is focused on the understanding and engineering of programmability in biology. These programmable systems, inspired by natural diversity, provide precise control over genomes, transcriptomes, and cellular identity, and are...
The Gredler lab investigates how dynamic cellular behaviors generate complex tissue structures during vertebrate development. We focus on the developing mouse embryo as a model to understand how cells coordinate their behaviors in space and time to drive...
Our group studies patterns of rare genetic variation in large collections of human genomic data, both from patients and reference population individuals, and designs tools and methods to help interpret that variation. We are focused on moving from...
Gene expression control is fundamental to all biological systems and is primarily mediated by transcription factors (TFs) that bind specific DNA sequences. This control is quantitative—approximately 50% reductions in TF levels cause rare disorders, while...
The Tsvetkov Lab investigates how metal homeostasis and metabolic regulation intersect to control cell fate, with a particular focus on copper biology and mitochondrial metabolism. We combine high-throughput chemical-genomic approaches with molecular and...
The Tsai Laboratory studies transcription factor protein stability and developing new methods to target transcription factors for degradation to treat disease. Many proteins are removed through ubiquitination and proteasomal degradation; recent studies...
