BBS Faculty

Vijay G. Sankaran

Jan Ellen Paradise, MD Professor of Pediatrics

Our laboratory utilizes human genetic approaches to gain insight into blood cell production (hematopoiesis) and how this process is perturbed in disease states. We study rare genetic blood disorders and the genetics underlying variation in hematopoiesis...

David T. Scadden

david_scadden@harvard.edu

Professor of Stem Cell and Regenerative Biology

The Scadden laboratory focuses on blood: how it is made, how it is corrupted in malignancy and how understanding it can lead to new therapies. We think of bone marrow as the perfect system to examine tissue systems biology. We combine in vivo imaging...

Jean Schaffer

jean.schaffer@joslin.harvard.edu

Ory Family Professor of Medicine

Excess lipid accumulation in non-adipose tissues is associated with lipotoxicity — cellular dysfunction and cell death that is linked to the pathogenesis of complications of diabetes and obesity. Our goal is to understand ways in which environmental cues...

Aaron Schmidt

aaron_schmidt@hms.harvard.edu

Associate Professor of Microbiology

Title: Using protein engineering, antibody evolution and small-molecule discovery to dissect host-pathogen interactions Key words: Protein engineering, viral evolution, host-pathogen interactions, small-molecule discovery Our research focuses on the...

Ralph Scully

rscully@bidmc.harvard.edu

Professor of Medicine

We study the relationships between mammalian double strand break (DSB) repair, genomic instability and cancer. Two major pathways contribute to DSB repair: homologous recombination (HR) and non-homologous end joining (NHEJ). Each plays a key role in...

Brian Seed

bseed@ccib.mgh.harvard.edu

Professor of Genetics

Work in our lab is centered on approaches to identify interesting genes and pathway connections using automated methods for analysis of function. We have amassed a collection of high efficiency expression plasmids that encompass a large fraction of the...

Rosalind Segal

rosalind_segal@dfci.harvard.edu

Professor of Neurobiology

During development, signaling pathways initiated by extracellular growth factors regulate and coordinate proliferation, differentiation, migration and survival. Understanding growth factor signaling pathways identifies critical steps in development and...

Michael Segel

michael_segel@harvard.edu

Assistant Professor of Stem Cell & Regenerative Biology

The Segel lab is interested in the evolution of mammalian lifespan. From single cells to whole organisms, we are interested in the molecular pathways that govern the pacing of postnatal mammalian development.

Christine Edry Seidman

cseidman@genetics.med.harvard.edu

Thomas W. Smith Professor of Medicine

The Seidman laboratory uses genetic techniques to study the molecular basis of inherited human disorders. A central project in the laboratory has been to understand the genetic basis of inherited cardiovascular diseases. Genetic work on Familial...

Jonathan G. Seidman

seidman@genetics.med.harvard.edu

Henrietta B. and Frederick H. Bugher Foundation Professor of Genetics

Work in the Seidman laboratory (Dept of Genetics, HMS) is directed toward identifying gene defects that cause inherited heart disease and defining the pathways by which these mutations mediate disease. We begin by using human genetic techniques to...

Dennis J. Selkoe

dselkoe@partners.org

Vincent and Stella Coates Professor of Neurologic Diseases

Our laboratory is interested in the biochemistry and molecular and cell biology of neuronal degeneration during aging of the mammalian brain, particularly in Alzheimer's (AD) and Parkinson's (PD) diseases. The laboratory originally developed methods for...

William Sellers

wsellers@broadinstitute.org