BBS Faculty

Nicholas Polizzi

nicholasf_polizzi@dfci.harvard.edu

Assistant Professor of BCMP

Most proteins function by first binding a ligand, such as another protein, peptide, or small molecule. The Polizzi laboratory aims to learn the rules of protein–ligand binding through the lens of de novo protein design. In de novo design, a protein’s...

Kornelia Polyak

kornelia_polyak@dfci.harvard.edu

Professor of Medicine

Our goal is to identify differences between normal and cancerous breast tissue, determine their consequences, and use this information to improve the clinical management of breast cancer patients. The three main areas of our interests are: (1) how to...

Olivier Pourquie

pourquie@genetics.med.harvard.edu

Frank Burr Mallory Professor of Pathology

We are interested in the development of the vertebrate musculo-skeletal axis. Using chicken and mouse embryos as model systems, we combine developmental biology and genomic approaches to study patterning and differentiation of the precursors of muscles...

William Pu

william.pu@cardio.chboston.org

Assistant Professor

The Pu laboratory studies cardiovascular development and disease, with a goal of developing new therapies for pediatric heart disease. We integrate molecular biology, functional genomics, cardiac physiology, genome editing, stem cell biology...

Pere B. Puigserver

pere_puigserver@dfci.harvard.edu

Professor of Cell Biology

Our lab investigates broad aspects of fundamental metabolic and energetic processes in mammals that are necessary for cell survival and specific biological function. We combine and apply a variety of biochemical, cellular, genetic, chemical biology...

Srivatsan Raghavan

srivatsan_raghavan@dfci.harvard.edu

Assistant Professor

The Raghavan Lab at Dana-Farber Cancer Institute and Harvard Medical School is a basic and translational oncology lab focused on understanding mechanisms of cell state regulation in cancer, evaluating how cell state plasticity influences therapeutic...

Jay Rajagopal

JRajagopal@partners.org

Professor of Medicine

My research program is focused on understanding airway regeneration and lung stem cell biology. We explore topics in fundamental stem cell biology such as size regulation, stem cell maintenance and regulation, metaplasia, epithelial organization, cell...

Seth Rakoff-Nahoum

seth.rakoff-nahoum@childrens.harvard.edu

Associate Professor of Pediatrics

Despite the growing recognition of the importance of the microbiota to humans, there are fundamental aspects of the microbiota and its relation to the host that are largely unexplored. These range from knowledge of the basic biology of individual strains...

Tom A. Rapoport

tom_rapoport@hms.harvard.edu

Professor of Cell Biology

We are interested in the molecular mechanisms by which proteins are transported across the endoplasmic reticulum (ER) membrane. Proteins are transported through a protein-conducting channel, formed from a conserved trimeric membrane protein complex...

Mohammad Rashidian

Mohammad_Rashidian@dfci.harvard.edu

Assistant Professor of Radiology

The Rashidian Lab studies cancer immunology and autoimmune disease using expertise in molecular biology, chemical biology and immunology.

Soumya Raychaudhuri

soumya@broadinstitute.org

Professor of Medicine

Immune-mediated diseases such as lupus or rheumatoid arthritis are not caused by an isolated insult resulting in a single dysfunctional gene or pathway, but rather a systemic dysregulation of multiple genes and pathways. Our group uses methods in...

David E. Reich

reich@genetics.med.harvard.edu

Professor of Genetics

Ancient DNA, Biology, and Disease (1) Building an Ancient DNA Atlas of Humanity: Ancient DNA allows us to go beyond the two-dimensional understanding of human genetic variation based on the coordinates of latitude and longitude, and to develop a far more...