Chronic pain and headache disorders are two leading causes of disability world-wide. Improving treatments for these conditions is a major focus of my lab as well as my clinical practice as a neurologist. The experience of pain begins with specialized...
The Gredler lab investigates how dynamic cellular behaviors generate complex tissue structures during vertebrate development. We focus on the developing mouse embryo as a model to understand how cells coordinate their behaviors in space and time to drive...
Our research explores how we learn from our mistakes—a fundamental building block of intelligent behavior. As infants learning to walk, we take unsteady steps, fall, adjust, and eventually develop stable locomotion. This iterative cycle of action, error...
Our lab studies the molecular and cellular basis of novel organismic physiology and behavior. We emphasize curiosity-driven science and exploration, using comparative approaches featuring a range of unusual and specialized organisms that are uniquely...
Research in the Wolfson lab is focused on understanding how we sense our internal environment. Sensory neurons that innervate internal organs have cell bodies that reside in the dorsal root ganglia, the DRG sensory neurons. These neurons must respond to a...
During development, signaling pathways initiated by extracellular growth factors regulate and coordinate proliferation, differentiation, migration and survival. Understanding growth factor signaling pathways identifies critical steps in development and...
The Rashidian Lab studies cancer immunology and autoimmune disease using expertise in molecular biology, chemical biology and immunology.
Our lab studies the development, function, and dysfunction of somatosensory and viscerosensory circuits that mediate our sense of touch and sensations from the gastrointestinal (GI) system, respectively. We are interested in how sensory experience...
Our current research includes three themes. First, we are studying the role of non-canonical nucleic acid structures, G-quadruplex (G4) and R-loop in gene expression, both at the level of transcription and translation in e.coli and mammalian cells. G4 is...
My lab explores signal transduction pathways in the cells and tissues of the cardiovascular system. We have a particular focus on applying biochemical methods and cell imaging approaches using informative biosensors to probe nitric oxide synthase...
