The Abudayyeh-Gootenberg lab is focused on the understanding and engineering of programmability in biology. These programmable systems, inspired by natural diversity, provide precise control over genomes, transcriptomes, and cellular identity, and are...
The Tsvetkov Lab investigates how metal homeostasis and metabolic regulation intersect to control cell fate, with a particular focus on copper biology and mitochondrial metabolism. We combine high-throughput chemical-genomic approaches with molecular and...
We study the relationships between mammalian double strand break (DSB) repair, genomic instability and cancer. Two major pathways contribute to DSB repair: homologous recombination (HR) and non-homologous end joining (NHEJ). Each plays a key role in...
We seek to elucidate mechanisms of disease and develop novel therapeutics through understanding underlying processes of innate and adaptive immunity that cause disease or are responsible for organ repair and regeneration. The major areas of interest of...
Bioenergetics and Energy Homeostasis
My laboratory studies the molecular basis of bioenergetics in health and disease, i.e., how we coordinate metabolic demands and control energy homeostasis, and how the processes go wrong in metabolic diseases, cancer...
The major focus of our laboratory is to investigate the cell and molecular biology of cancer, with a focus on the PI 3-Kinase and AKT signaling pathway in cancer. We have investigated the regulation and function of the Akt/PKB and SGK protein kinases...
My lab has pioneered various aspects of the microRNA field and continues to make important contributions to this aspect of post-transcriptional control of gene regulation in stem cell development, cancer and aging. For example we are co-discoverers of the...
Our laboratory researches how cancer cells develop drug resistance, and more specifically, how the tumor microenvironment provides support and protection to tumor cells. Results from these studies will allow us to develop better strategies to overcome...
The goal of my lab is to understand the regulatory relationship between cellular signaling pathways and metabolic pathways. We are particularly interested in the PI3K (phosphoinositide-3-kinase) signaling pathway which is a major regulator of glucose and...
