The Gredler lab investigates how dynamic cellular behaviors generate complex tissue structures during vertebrate development. We focus on the developing mouse embryo as a model to understand how cells coordinate their behaviors in space and time to drive...
The Segel lab is interested in the evolution of mammalian lifespan. From single cells to whole organisms, we are interested in the molecular pathways that govern the pacing of postnatal mammalian development.
The broad interest of the WAGERS LAB is to identify and analyze tissue-specific stem cell populations in adult animals. This work focuses on understanding the factors controlling the migration and expansion of bone marrow-derived and blood-forming...
My laboratory uses a stem cell based approach to understand neurodegenerative diseases, particularly orphan diseases such as Spinal Muscular Atrophy, so that we can identify potentially new therapeutic targets. Our work is based on using disease relevant...
The heart, like all internal organs, has its own local mini-brain. Nerve cells designed to sense the microenvironment connect to other neurons and to heart muscle and to pacemaker cells. This circuit sends signals to the brain and, in turn, is regulated...
Humans and other mammals have extremely limited regenerative capabilities in key parts such as limbs. Nearly two million Americans are currently living with the consequences of having undergone limb amputation due to injury or disease, and this number is...
We study how epithelial tissues generate the right cells in the right places as they renew and regenerate during adulthood.
Our lab focuses on two of the most dynamic organ systems in mammals: the small intestine and the uterus. The intestinal epithelium...
Our laboratory is directed toward both 1) understanding molecular controls and mechanisms over neuron sub-type development, diversity, axon guidance-circuit formation, and degeneration-disease in the cerebral cortex (e.g. corticospinal motor neurons -...
My research laboratory is a part of the Brigham Regenerative Medicine Center, a research program I direct. My laboratory's approach is to understand important problems at a molecular level, design solutions in the laboratory and then demonstrate the...
For many years our research group has been interested in the molecular mechanisms of various antibiotics and the fundamental cellular processes they inhibit. We have primarily focused on drugs that target bacterial cell wall biosynthesis, including the...
