3D Map of Cell Signaling Sites Could Help Improve Cancer Treatment
Tool can identify kinase activity in cancer cells, inform use of kinase inhibitors
Cell-communication molecules called kinases play a key role in the growth and spread of many cancers. But exactly which kinases are active in a particular cancer is not always clear — there are 1.8 million sites on human proteins that kinases might act on, and researchers have fully characterized less than 1 percent of them.
A Harvard Medical School team has now built an AI-enabled tool called KinoPlex that maps the three-dimensional structures and biochemical environments of all of these sites and matches them with the specific kinases that can interact with them.
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