New Screening Approach Expands Search for Compounds That Destroy Disease-Causing Proteins
Platform identifies molecular glue degraders, which harness cells’ waste disposal systems
Harvard Medical School investigators at Dana-Farber Cancer Institute have developed a new laboratory method for systematically discovering molecular glue degraders — compounds that harness cells’ own waste-disposal machinery to destroy disease-causing proteins, including proteins that have been difficult to target with traditional drugs.
The new platform, reported Aug. 5 in Nature, could dramatically expand the search for molecular glue-based drugs, including protein degraders. Already, it has revealed a new way that molecular glue degraders can work.
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