Researchers Create Molecular Map of Hypertrophic Cardiomyopathy
Findings from nearly 1 million heart cells could inform more precise treatments
An international team led by researchers from Harvard Medical School, Brigham and Women’s Hospital, and the Max Delbrück Center for Molecular Medicine in Germany has created a detailed map of the molecular activity underlying hypertrophic cardiomyopathy (HCM), a common form of heart disease that causes the heart muscle to become thick and stiff and can lead to heart failure or sudden cardiac arrest.
The findings, published Sept. 16 in Science Translational Medicine, provide insights into the changes that drive HCM, which could in turn inform current and future treatments.
“Charting the molecular landscape of hypertrophic cardiomyopathy is essential for advancing our understanding of the disease, improving patient care, and developing new therapeutic approaches,” said co-senior author Christine Seidman, the HMS Thomas W. Smith Professor of Medicine at Brigham and Women’s and professor of genetics at HMS.
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