Scientists Reveal How the Monkeypox Virus Replicates
Findings deepen understanding of what drives infection, could inform new therapies
The way a duo of monkeypox virus proteins change shape as they bind together acts like a switch that starts the process of viral replication, a study led by researchers in the Blavatnik Institute at Harvard Medical School reveals.
This kind of detailed structural information promises to help scientists, armed with a new generation of AI-powered virtual screening tools, target their search for ways to inhibit viral replication, treat mpox and related diseases, and prepare for emerging pathogens.
“Learning as much as we can about as many different potential threats as we can is the best way to be ready for the pathogens we will face in the future,” said study co-senior author Jonathan Abraham, professor of microbiology at HMS.
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