‘Molecular Movie’ Fills in Blanks of How Non-Enveloped Viruses Infect Cells
Cryo-ET of rotavirus answers decades-old virology question, could inform drug delivery techniques
- Researchers have answered a longstanding question about how certain non-enveloped viruses punch through the cell membrane to deliver their genetic material.
- The findings deepen understanding of virology and could aid the biotech industry’s search for ways to deliver relatively large therapeutic agents into cells to treat or prevent disease.
- Work was made possible by an advanced imaging technique known as cryo-electron tomography, or cryo-ET, at HMS.
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