Lipid signaling in immunity and inflammatory disease
My laboratory studies the biology of the bioactive lipid mediator- sphingosine 1-phosphate (S1P), a fundamental regulator of immune and vascular systems. The vertebrate immune system co-evolved with the...
Our research is devoted to understanding the regulation of neuronal connectivity and synaptogenesis. We combine genetic approaches with molecular biology, sophisticated imaging, and behavioral assays to understand the cell biological mechanisms necessary...
The laboratory studies the genetic basis by which form and structure are regulated during vertebrate development. In this work, we combine classical methods of experimental embryology with modern molecular and genetic techniques for regulating gene...
We are interested in the development of the vertebrate musculo-skeletal axis. Using chicken and mouse embryos as model systems, we combine developmental biology and genomic approaches to study patterning and differentiation of the precursors of muscles...
The overarching goal of the Lassar lab is to understand how different cells types (i.e., articular or epiphyseal chondrocytes, ligaments and synoviocytes) emerge from a common precursor population during the formation of the synovial joint. Towards this...
Our broad interest is to understand how cell-cell signaling molecules set up spatial pattern, particularly in the formation of neuronal connections. We use a range of approaches including biochemical and cell biological studies, high-throughput analysis...
The step-by-step differentiation of embryonic cells into different types of neurons lays the foundation for our sensory responses, motor commands, and cognitive behaviors. Our research explores such differentiation programs in mammals using a combination...
