Our lab studies the molecular and cellular basis of novel organismic physiology and behavior. We emphasize curiosity-driven science and exploration, using comparative approaches featuring a range of unusual and specialized organisms that are uniquely...
The Segel lab is interested in the evolution of mammalian lifespan. From single cells to whole organisms, we are interested in the molecular pathways that govern the pacing of postnatal mammalian development.
My lab explores signal transduction pathways in the cells and tissues of the cardiovascular system. We have a particular focus on applying biochemical methods and cell imaging approaches using informative biosensors to probe nitric oxide synthase...
Our lab studies the molecular mechanisms of sensory transduction, seeking to understand how animals detect the physical and chemical cues from their environment and transform them into cellular signals. In particular, we focus on the sense of smell in...
We are exploring pathogen-host interactions, particularly in the context of animal models relevant to human infection of clinically important enteric pathogens including Vibrio cholerae, Vibrio parahaemolyticus and enterohemorrhagic Escherichia coli (EHEC...
The laboratory studies the genetic basis by which form and structure are regulated during vertebrate development. In this work, we combine classical methods of experimental embryology with modern molecular and genetic techniques for regulating gene...
We study how epithelial tissues generate the right cells in the right places as they renew and regenerate during adulthood.
Our lab focuses on two of the most dynamic organ systems in mammals: the small intestine and the uterus. The intestinal epithelium...
Research in our lab revolves primarily around aging, lifespan control and rejuvenation.
We also have had longstanding interests in selenium and redox biology.
Understanding mechanisms of lifespan control through longevity signatures
Mice live 3 years...
