The Mekalanos laboratory is engaged in the analysis of bacterial virulence and functional genomics. The goal of these studies is to understand how pathogenic bacteria grow, evade the host immune system and ultimately cause disease. A variety of organisms...
My research program focuses on studying mRNA translation in parasites that significantly burden global health, including Leishmania, Babesia, and Plasmodium organisms.
Our efforts notably center on characterizing translation initiation factors and...
The laboratory focuses on understanding how small molecules, particularly those from bacteria and fungi, control biological processes. Organizing themes include: 1) function-based discovery of microbially-produced small molecules and their roles in...
Our goal is to understand the role of neural-immune interactions in pain, host defense, and immunity. It is increasingly clear that microbes and immune cells release mediators that impact the health and function of the nervous system. Neurons also release...
Malaria remains a major public health threat with more than 225 million people infected worldwide and one fourth of the world's population is at risk for infection. More than a million children die from malaria each year, most of them in Africa. Drug...
The Dvorin Laboratory is part of the Division of Infectious Diseases at Boston Children's Hospital, the primary pediatric teaching hospital of Harvard Medical School. The research in our laboratory investigates the molecular pathogenesis of infection by...
We are interested in understanding transport mechanisms in the cell. In particular, we are interested in how molecules are transported into, out of, and within cilia. Cilia (also known as flagella) are finger-like organelles that project from the surface...
