The Mekalanos laboratory is engaged in the analysis of bacterial virulence and functional genomics. The goal of these studies is to understand how pathogenic bacteria grow, evade the host immune system and ultimately cause disease. A variety of organisms...
My research program focuses on studying mRNA translation in parasites that significantly burden global health, including Leishmania, Babesia, and Plasmodium organisms.
Our efforts notably center on characterizing translation initiation factors and...
The laboratory focuses on understanding how small molecules, particularly those from bacteria and fungi, control biological processes. Organizing themes include: 1) function-based discovery of microbially-produced small molecules and their roles in...
Malaria remains a major public health threat with more than 225 million people infected worldwide and one fourth of the world's population is at risk for infection. More than a million children die from malaria each year, most of them in Africa. Drug...
