Our lab studies the molecular and cellular basis of novel organismic physiology and behavior. We emphasize curiosity-driven science and exploration, using comparative approaches featuring a range of unusual and specialized organisms that are uniquely...
Our lab studies signals that regulate the specification and maintenance of cell differentiation during early embryogenesis, tissue regeneration, and disease pathogenesis. We study embryogenesis and regeneration using frog embryos and tadpoles as a model...
We use frog egg extracts to study the molecular mechanisms underlying DNA replication and repair, and how these processes go awry in human disease. We are working on the following areas:
1. DNA cross-link repair. Our cells are constantly exposed to...
Our research is devoted to understanding the regulation of neuronal connectivity and synaptogenesis. We combine genetic approaches with molecular biology, sophisticated imaging, and behavioral assays to understand the cell biological mechanisms necessary...
Our lab has two main interests: 1) Understanding the mechanisms involved in cell-cell signaling through the vertebrate Hedgehog pathway; and 2) Synthesizing and validating new chemical probes for microscopic imaging and functional assays of various...
We are interested in the molecular mechanisms by which proteins are transported across the endoplasmic reticulum (ER) membrane. Proteins are transported through a protein-conducting channel, formed from a conserved trimeric membrane protein complex...
My lab is interested in the structure, dynamics, and function of the cytoskeleton. We use imaging-based assays in living cells and in vitro extracts, in conjunction with molecular biology and biochemical fractionation approaches, as well as theory and...
Single-Molecule Studies of Genome Maintenance
Our laboratory is interested in developing and applying single-molecule methods to better understand the molecular dynamics of multi-protein complexes that carry out duplication, maintenance and transmission of...
Our lab has focused on understanding cell morphogenesis, cell proliferation, and cell signaling by combining biochemical, cell biological, and embryological approaches. We are also interested in the evolution of vertebrates through studies of hemichordate...
Our goal is to develop new approaches for treating human disease, based on our understanding of fundamental cell biological principles. We start by identifying new compounds that perturb complex cellular pathways, and then use the compounds as tools to...
