Haribabu Arthanari

Haribabu Arthanari

Assistant Professor of Biological Chemistry and Molecular Pharmacology
Haribabu Arthanari
Protein-Protein Interactions (PPIs) is the Holy Grail of therapeutic intervention, offering a plethora of distinct structural landscapes that can be targeted with high specificity. Arthanari lab uses structure-guided approaches to characterize and validate these interactions in the context of disease models.  We utilize a combination of techniques including NMR spectroscopy, high throughput screening, and biophysical and cell-based assays to map hotspots in the interaction interface, to further understand the molecular mechanisms orchestrated by these interactions, and to identify disruptive inhibitors that may be developed into treatments for the related pathologies. Our current areas of focus are 1) the critical interactions between transcription factors and the general transcriptional machinery, including the Mediator complex, co-activators, and remodeling factors, and 2) translation initiation machinery demonstrated to be dysregulated in cancer disease states.  Our work on novel NMR methods let us push the boundaries of NMR as a technique, allowing us to tackle larger and complex systems by NMR. We also develop NMR methods to dissect and uncover the secrets of the disordered part of the human proteome referred to as the “Dark Proteome"

Contact Information

Dana Farber Cancer Institute
Longwood Center, Room 3311
450 Brookline Avenue
Boston, MA 02115
p: 617-632-6422

Community or Program Affiliation

Organism

People