We are interested in the development of the vertebrate musculo-skeletal axis. Using chicken and mouse embryos as model systems, we combine developmental biology and genomic approaches to study patterning and differentiation of the precursors of muscles...
The focus of this laboratory is to understand the genetic basis of development of form – that is shape, size and proportion during vertebrate development. We focus on the skeleton of the adult fish as a model to understand the genetic basis of growth and...
Our laboratory is using cellular, molecular, bioengineering, and computational biology tools to understand how mechanical forces generated by the flow of blood act on blood vessels to activate signaling pathways critical for cellular specification during...
My research program is focused on understanding airway regeneration and lung stem cell biology. We explore topics in fundamental stem cell biology such as size regulation, stem cell maintenance and regulation, metaplasia, epithelial organization, cell...
Multicellular organisms are formed by a large number of cell types, which serve as the components of tissues and organs. In the Simoes-Costa Lab, we study how cellular diversity arises during vertebrate embryonic development. We employ systems-level...
My research laboratory is a part of the Brigham Regenerative Medicine Center, a research program I direct. My laboratory's approach is to understand important problems at a molecular level, design solutions in the laboratory and then demonstrate the...
Our lab has focused on understanding cell morphogenesis, cell proliferation, and cell signaling by combining biochemical, cell biological, and embryological approaches. We are also interested in the evolution of vertebrates through studies of hemichordate...
Our laboratory is directed toward both 1) understanding molecular controls and mechanisms over neuron sub-type development, diversity, axon guidance-circuit formation, and degeneration-disease in the cerebral cortex (e.g. corticospinal motor neurons -...
Ana completed her BS in Molecular, Cellular, and Developmental Biology at the University of Kansas. She studied paramutation in Drosophila virilis. Currently she is investigating how organisms (such as fission yeast) survive a novel transposon invasion...
The laboratory focuses on the developmental biology of hematopoiesis and cancer. We have collected over 30 mutants affecting the hematopoietic system. Some of the mutants represent excellent animal models of human disease. We also have undertaken...
Molecule analysis of blood cell development has served as an important paradigm for stem cell biology. We have obtained a solid foundation in understanding how commitment to specific lineages is programmed and cell-specific patterns of gene expression are...
How do cells sharing the same DNA produce drastically distinct phenotypes? In one organism, the same genome allows for the development of different tissues, controlled cell cycle progression, and specialized responses to environmental stimuli. This occurs...
