The Hacohen lab consists of immunologists, geneticists, biochemists, technologists, physicians and computational biologists working together to develop new and unbiased technologies and strategies to understand basic immune processes and immune-mediated...
We strive to discover genomic and infectious causes for human cancers. We then seek to apply these discoveries to understand mechanisms of cancer pathogenesis, and to improve cancer diagnosis and treatment. A particular focus is lung cancer pathogenesis...
Our research focuses on deciphering the molecular mechanisms of metabolic disease and dysfunction, and using this information to develop targeted therapeutic strategies. Dysfunction in a particular cellular locale – the mitochondrion – is implicated most...
The Naxerova lab’s research spans a variety of topics in cancer genetics and somatic evolution. We use interdisciplinary approaches to study the origins and consequences of somatic variation. We blend computational analysis, experimental work and...
The vertebrate immune system is capable of specifically recognizing and responding to an enormous number of antigens. The interaction with antigen is mediated by the immunoglobulin (Ig) and T cell receptor (TCR) molecules expressed by B and T lymphocytes...
The Tsai Laboratory studies transcription factor protein stability and developing new methods to target transcription factors for degradation to treat disease. Many proteins are removed through ubiquitination and proteasomal degradation; recent studies...
The Raghavan Lab at Dana-Farber Cancer Institute and Harvard Medical School is a basic and translational oncology lab focused on understanding mechanisms of cell state regulation in cancer, evaluating how cell state plasticity influences therapeutic...
Question
How can we measure the structures of RNAs in the cell? How does RNA regulate gene expression in normal cells, and what aspects go awry in the onset of disease states such as viral infections, neurodegeneration and cancer?
Approach
RNA viruses have...
Although numerous eukaryotic genomes have been sequenced, much still remains to be understood about how the genes in those genomes are regulated. The interactions between transcription factors (TFs) and their DNA binding sites are an integral part of the...
The Lieberman laboratory studies the innate and adaptive immune response to infection and cancer. They seek to understand how cytotoxic T lymphocytes and NK cells provide immune protection in some conditions and fail to function or cause immune pathology...
