The Horlbeck lab studies Chromatinopathies, a large class of genetic disorders in which disruption of chromatin modifying machinery leads to developmental delay and intellectual disability. The lab seeks to understand how chromatin regulation shapes cell...
There are clear resemblances between parents and children for height, weight, and many other traits and diseases; these familial resemblances are influenced strongly by inherited genetic factors. Most common diseases (such as diabetes, obesity, or asthma)...
Our laboratory utilizes human genetic approaches to gain insight into blood cell production (hematopoiesis) and how this process is perturbed in disease states. We study rare genetic blood disorders and the genetics underlying variation in hematopoiesis...
My laboratory is focused on understanding nervous system disease using molecular genetic strategies, beginning with human patients and proceeding through in vitro and modeling studies, with the ultimate goal of improving diagnosis, management and...
Data generated by the rapidly advancing DNA sequencing technology provide the complete picture of population genetic variation and sequence divergence between species. We have been focused on the analysis of systematic re-sequencing datasets with the goal...
The Seidman laboratory uses genetic techniques to study the molecular basis of inherited human disorders. A central project in the laboratory has been to understand the genetic basis of inherited cardiovascular diseases. Genetic work on Familial...
The laboratory studies the genetic basis by which form and structure are regulated during vertebrate development. In this work, we combine classical methods of experimental embryology with modern molecular and genetic techniques for regulating gene...
Our laboratory at Dana-Farber Cancer Institute is a basic and translational oncology laboratory focused on studying pancreatic cancer and other RAS-driven malignancies. We utilize genomic, functional genetic, molecular and cell biology approaches to...
We are working to understand (i) how the human genome varies from person to person, and (ii) how inherited genome variation affects the biology of neurons and microglia on its way to affecting brain phenotypes such as risk of bipolar disorder, autism and...
