The overall goal of our research is to achieve a greater understanding of the molecular basis of brain aging and how normal aging transitions to pathological aging, giving rise to neurodegenerative disorders such as Alzheimer's and Parkinson's disease...
Our lab aims to understand the in vivo functions of certain genes identified in neurodegenerative and developmental disorders of the human brain such as schizophrenia, Alzheimer's disease, lissencephaly, autism and mental retardation. We use a variety of...
Our research is focused on the nature of highly aggressive, metastatic, late-stage cancers. We believe that such tumors differ markedly from less aggressive tumors and respond to different drugs than either primary tumors or dormant metastases...
The Zhang lab is interested in how epigenetic modification-mediated dynamic changes in chromatin structure affects gene expression, stem cell reprogramming, germ cell development, beta-cell generation, and drug addiction. In the past decade, the lab has...
How do cells sharing the same DNA produce drastically distinct phenotypes? In one organism, the same genome allows for the development of different tissues, controlled cell cycle progression, and specialized responses to environmental stimuli. This occurs...
The Farnung Lab aims to answer key mechanistic questions at the intersection of chromatin and transcription. We employ biochemical, biophysical, and structural biology approaches to understand how the transcription machinery, histone modifying enzymes...
