We seek to use the vast knowledge of biology to predictably design biological systems to enhance our fundamental understanding and to provide solutions for real world problems.
Current projects use mammalian cells, simple eukaryotes and prokaryotes....
Why do we grow old? Why does aging cause disease? Can we slow aging or even reverse it? These are some of the greatest unsolved questions in biology. Advances in technology are allowing us to probe these questions more deeply and more rapidly than ever...
Structural Biology and Computing provide robust tools to dissect mechanisms of disease.
To fully elucidate reaction mechanisms, develop effective functional probes, or rationalize searches for small molecule inhibitors, one usually needs to determine the...
Using a combination of computational and experimental approaches we study the processes that determine whether mammalian cells live or die. Our lab is particularly interested in apoptosis triggered by extracellular ligands such as TRAIL, Fas and TNF and...
Diabetes and Obesity Genetics. The Soukas Laboratory in the Center for Human Genetic Research and the Diabetes Unit at the MGH seeks to understand the pathogenesis of obesity and diabetes, and to identify new therapeutic targets for these common...
My research focuses on understanding the relationship between genotype and phenotype, with a special interest in how biochemistry, molecular design, and wiring can allow cells to process information from their environment and respond appropriately. By...
We work on receptor-ligand interactions and signal transmission across membranes. We use a wide range of structural, cell biological, and single molecule techniques to answer important questions relevant to immunology, hemostasis, mammalian biology, and...
Research in our lab uses a combination of cellular and molecular approaches in the analysis of T-cell responses to bacterial pathogens. Many virulence factors have been identified which allow bacteria to survive and replicate within the mammalian host...
For a living cell to function properly, its cellular processes must be strictly controlled not only in time but also in space. We are interested in how intracellular spatial organization on the micron-length scale is achieved by nanometer-sized proteins...
The laboratory studies the genetic basis by which form and structure are regulated during vertebrate development. In this work, we combine classical methods of experimental embryology with modern molecular and genetic techniques for regulating gene...
Our research is devoted to understanding the regulation of neuronal connectivity and synaptogenesis. We combine genetic approaches with molecular biology, sophisticated imaging, and behavioral assays to understand the cell biological mechanisms necessary...
We are trying to understand how circulating cells manage to leave the blood stream and home to distinct organs or tissues where they may have crucial physiologic functions or may cause disease. Despite considerable progress in this field, it is still...
