Structural Biology and Computing provide robust tools to dissect mechanisms of disease.
To fully elucidate reaction mechanisms, develop effective functional probes, or rationalize searches for small molecule inhibitors, one usually needs to determine the...
I am a computational biologist studying the role of chromatin structure/dynamics and non-coding regions including enhancers, promoters, insulators and their role in gene regulation. The mission of my lab is the integration of omics data to explore and...
Most proteins function by first binding a ligand, such as another protein, peptide, or small molecule. The Polizzi laboratory aims to learn the rules of protein–ligand binding through the lens of de novo protein design. In de novo design, a protein’s...
Data generated by the rapidly advancing DNA sequencing technology provide the complete picture of population genetic variation and sequence divergence between species. We have been focused on the analysis of systematic re-sequencing datasets with the goal...
Mutational processes in cancer and normal cells; development of computational methods for genome and epigenome analysis.
We employ computational and statistical approaches to study various types of somatic mutations that arise in cancer cells and neurons...
Dr. Daly's lab focuses on computational approaches to understanding the genetics of disease with a strategy of integrating powerful techniques from human and mouse genetics. The lab has extensive experience in linkage and association analysis and has...
1. Using data from a high-throughput experimental assay, we have developed a computational algorithm that predicts the genotypic outcomes of template-free CRISPR/Cas9 genome editing. This modeling has uncovered that CRISPR/Cas9 outcomes are highly...
The Naxerova lab’s research spans a variety of topics in cancer genetics and somatic evolution. We use interdisciplinary approaches to study the origins and consequences of somatic variation. We blend computational analysis, experimental work and...
Pathologists have observed alterations of nuclear structure for over a century. These morphologic nuclear changes are routinely used in cancer diagnostics, however the molecular underpinnings of these changes remain largely unknown. The Johnstone lab is...
Although numerous eukaryotic genomes have been sequenced, much still remains to be understood about how the genes in those genomes are regulated. The interactions between transcription factors (TFs) and their DNA binding sites are an integral part of the...
Cancer represents one of the biggest problems for modern societies. In 2010, there were 1.53 million new cancer cases and 570,000 cancer-related deaths in the US, leading to an overall cost of $264 billion. By 2020, cancer deaths worldwide could reach 10...
