We are a collaborative group of genome editing scientists at the Translational Neuroscience Center of Boston Children’s Hospital and Harvard Medical School department of Neurology. We strive to develop gene-based therapeutics for genetic neurological...
Half of our genome consists of repeat sequences that resemble viral DNA, yet the functional significance of these virus-like repeats remains a mystery. Abnormal repeat sequences have been found at unstable genomic regions implicated in cancer and genetic...
Genomics of human disease. We are interested in the functional consequences of the complete spectrum of genomic variation on human disease, with a particular focus on congenital birth defects, autism, neurodevelopmental disorders, and diverse...
We are working to understand (i) how the human genome varies from person to person, and (ii) how inherited genome variation affects the biology of neurons and microglia on its way to affecting brain phenotypes such as risk of bipolar disorder, autism and...
The Kleinstiver group takes engineering-focused approaches to develop new genome engineering technologies for research applications and for the treatment of human diseases. They have synergistic efforts in the fields of genome editing technology...
We are interested in the fundamental mechanisms of neurodegenerative disorders like Alzheimer’s disease. Over the past century-plus, research has revealed specific proteins that misfold and are deposited in neurodegeneration, and recent discoveries have...
I am a computational biologist studying the role of chromatin structure/dynamics and non-coding regions including enhancers, promoters, insulators and their role in gene regulation. The mission of my lab is the integration of omics data to explore and...
The O’Donnell-Luria laboratory studies how genetic variation contributes to the development of rare disease in humans. While individually rare, these conditions collectively affect ~5% of the population. Half of patients remain undiagnosed after clinical...
The Lemieux laboratory investigates the pathogenesis and epidemiology tick-borne and respiratory pathogens using computational and experimental methods. Our primary focus is defining and characterizing the microbial genetic factors that influence Lyme...
Pathologists have observed alterations of nuclear structure for over a century. These morphologic nuclear changes are routinely used in cancer diagnostics, however the molecular underpinnings of these changes remain largely unknown. The Johnstone lab is...
Our laboratory aims to understand normal cell division mechanisms and to discover cell division defects that are unique to cancer cells. We take a range of approaches including genetics, functional genomics, biochemistry and live cell imaging. There are...
