Our research is focused on the nature of highly aggressive, metastatic, late-stage cancers. We believe that such tumors differ markedly from less aggressive tumors and respond to different drugs than either primary tumors or dormant metastases...
The Abudayyeh-Gootenberg lab, based at the Mass General Brigham Gene and Cell Therapy Institute, Beth Israel Deaconess Medical Center, and Harvard Medical School, is dedicated to exploring programmable systems in biology for the development of molecular...
The Tsvetkov Lab investigates how metal homeostasis and metabolic regulation intersect to control cell fate, with a particular focus on copper biology and mitochondrial metabolism. We combine high-throughput chemical-genomic approaches with molecular and...
Bioenergetics and Energy Homeostasis
My laboratory studies the molecular basis of bioenergetics in health and disease, i.e., how we coordinate metabolic demands and control energy homeostasis, and how the processes go wrong in metabolic diseases, cancer...
The major focus of our laboratory is to investigate the cell and molecular biology of cancer, with a focus on the PI 3-Kinase and AKT signaling pathway in cancer. We have investigated the regulation and function of the Akt/PKB and SGK protein kinases...
The goal of my lab is to understand the regulatory relationship between cellular signaling pathways and metabolic pathways. We are particularly interested in the PI3K (phosphoinositide-3-kinase) signaling pathway which is a major regulator of glucose and...
The Abudayyeh-Gootenberg lab is focused on the understanding and engineering of programmability in biology. These programmable systems, inspired by natural diversity, provide precise control over genomes, transcriptomes, and cellular identity, and are...
We study the relationships between mammalian double strand break (DSB) repair, genomic instability and cancer. Two major pathways contribute to DSB repair: homologous recombination (HR) and non-homologous end joining (NHEJ). Each plays a key role in...
My lab has pioneered various aspects of the microRNA field and continues to make important contributions to this aspect of post-transcriptional control of gene regulation in stem cell development, cancer and aging. For example we are co-discoverers of the...
We seek to elucidate mechanisms of disease and develop novel therapeutics through understanding underlying processes of innate and adaptive immunity that cause disease or are responsible for organ repair and regeneration. The major areas of interest of...
Our laboratory researches how cancer cells develop drug resistance, and more specifically, how the tumor microenvironment provides support and protection to tumor cells. Results from these studies will allow us to develop better strategies to overcome...
