Protein-based heredity in bacteria. With a primary emphasis on bacterial genetics, our laboratory uses bacteria to study prions and protein-based heredity. Prions are infectious, self-propagating protein aggregates (typically amyloid) that are notorious...
Our laboratory pursues both basic and translational studies to understand and treat infections caused by intestinal bacteria. Areas of interest described below include the impact of intestinal pathogens on host metabolism and nutrition, development of...
The research efforts in the laboratory are directed towards understanding the molecular basis of pathogenesis of human infections caused by opportunistic gram-negative bacteria. We have used Pseudomonas aeruginosa as a model opportunistic pathogen...
The van Opijnen Lab works at the intersection of microbial systems biology, functional genomics, and computational modeling. Our central focus is understanding how bacterial pathogens survive the combined assault of host immunity and antibiotic treatment...
Work in the Rudner lab focuses on fundamental questions in bacterial cell biology and development: How do bacteria enter and exit dormancy? How are replicated chromosomes organized and segregated? How is the cell envelope remodeled during growth and...
The increasing emergence of bacterial strains resistant to antibiotics is far outpacing our ability to develop novel therapies to treat these infections. Further, the methodologies used to both diagnose infection and predict appropriate courses of...
For many years our research group has been interested in the molecular mechanisms of various antibiotics and the fundamental cellular processes they inhibit. We have primarily focused on drugs that target bacterial cell wall biosynthesis, including the...
Research in our lab uses a combination of cellular and molecular approaches in the analysis of T-cell responses to bacterial pathogens. Many virulence factors have been identified which allow bacteria to survive and replicate within the mammalian host...
We are exploring pathogen-host interactions, particularly in the context of animal models relevant to human infection of clinically important enteric pathogens including Vibrio cholerae, Vibrio parahaemolyticus and enterohemorrhagic Escherichia coli (EHEC...
Ancient signaling pathways lie at the base of the initiation of immunity, serving to transmit signals from Pattern Recognition Receptors (PRRs) to trigger the activation of anti-microbial defenses. All PRRs, which evolved to detect potentially pathogenic...
My lab studies the interplay between the gut microbiome and the immune system and how their “miscues” can lead to autoimmune diseases, particularly type 1 diabetes. As a 2013 BBS grad, I understand what it takes to have a successful Ph.D. experience.
The...
The long-term goal of the Devlin lab is to understand and control the chemistry of human-associated bacteria in order to uncover how the microbiome affects human health and disease.
We are not alone. The human body harbors more bacterial cells than human...