The Kleinstiver group takes engineering-focused approaches to develop new genome engineering technologies for research applications and for the treatment of human diseases. They have synergistic efforts in the fields of genome editing technology...
Our research focuses on the molecular mechanism of membrane channels, receptors, and transporters. We have been using solution NMR spectroscopy to study these proteins, while pushing the technological envelope to enable NMR characterization of the...
The human brain—and the diseases that afflict it—present unique challenges for experimental study, chief among them being tissue availability (only at postmortem) and profound cell non-autonomy in tissue function. Our lab seeks to develop technologies...
Our laboratory has three major areas of interest.
Human Genetics. We have been interested in cloning human disease genes, understanding how mutations in individual genes cause human disease and what approaches can be used to develop therapies for such...
Our laboratory seeks to advance our understanding of gene regulation biology using single-cell methods. To do this, we develop new technologies that integrate molecular biology, microscopy, and large-scale bioinformatics. These efforts include new methods...
Technology drives biological research. A new technology can instantly provide answers that were difficult or impossible to address using current approaches. The emerging field of proteomics provides researchers an alternative/complementary strategy to the...
Though much of what defines a human is encoded in the sequence of our DNA, many additional factors influence how this genetic information is manifest. For example, heritable epigenetic information contained within chromatin, the higher-order structure...
The overarching goal of the Jost lab is to define the molecular mechanisms of host-microbiome communication using a combination of systematic CRISPR technologies, physiological cell models such as organoids, and an interdisciplinary set of targeted...
Our research focuses on new technologies for genomic & proteomic measurement, synthesis and modeling of biomedical & ecological systems -- in particular, personal genomics and biofuels. We have developed next-generation sequencing methods to analyze the...
The Zhang lab is interested in how epigenetic modification-mediated dynamic changes in chromatin structure affects gene expression, stem cell reprogramming, germ cell development, beta-cell generation, and drug addiction. In the past decade, the lab has...
Our lab is focused on development and application of proteomics-based methods for in-depth analysis of key molecular events in tumorogenesis. Given the highly dynamic nature of biological processes, we are particularly interested in novel and robust...
The Abudayyeh-Gootenberg lab is focused on the understanding and engineering of programmability in biology. These programmable systems, inspired by natural diversity, provide precise control over genomes, transcriptomes, and cellular identity, and are...
