The heart, like all internal organs, has its own local mini-brain. Nerve cells designed to sense the microenvironment connect to other neurons and to heart muscle and to pacemaker cells. This circuit sends signals to the brain and, in turn, is regulated...
Our laboratory is interested in the intersection of normal hematopoietic development and blood diseases. Our research is rooted in the fundamental observation that adults and children are affected by different blood diseases. We believe that this is due...
Restoring lost function after spinal cord injury or other types of CNS injuries is a major challenge of contemporary neuroscience. A key culprit of functional deficits is the disruption and/or dysfunction of axonal connections connecting different parts...
The laboratory focuses on the developmental biology of hematopoiesis and cancer. We have collected over 30 mutants affecting the hematopoietic system. Some of the mutants represent excellent animal models of human disease. We also have undertaken...
My lab has pioneered various aspects of the microRNA field and continues to make important contributions to this aspect of post-transcriptional control of gene regulation in stem cell development, cancer and aging. For example we are co-discoverers of the...
1. Using data from a high-throughput experimental assay, we have developed a computational algorithm that predicts the genotypic outcomes of template-free CRISPR/Cas9 genome editing. This modeling has uncovered that CRISPR/Cas9 outcomes are highly...
The Scadden laboratory focuses on blood: how it is made, how it is corrupted in malignancy and how understanding it can lead to new therapies. We think of bone marrow as the perfect system to examine tissue systems biology. We combine in vivo imaging...
My research program is focused on understanding airway regeneration and lung stem cell biology. We explore topics in fundamental stem cell biology such as size regulation, stem cell maintenance and regulation, metaplasia, epithelial organization, cell...
Hematopoietic stem cells (HSCs) can give rise to each of the blood lineages present throughout a vertebrate’s lifetime. The gene programs and signaling networks regulating HSC development and function in the embryo and adult are highly evolutionarily...
The Megason Lab uses imaging-based systems biology to elucidate the systems level principles of animal development. We are particularly interested in long standing problems in embryology whose understanding has defied molecular reduction namely patterning...
