Chronic pain and headache disorders are two leading causes of disability world-wide. Improving treatments for these conditions is a major focus of my lab as well as my clinical practice as a neurologist. The experience of pain begins with specialized...
The Gredler lab investigates how dynamic cellular behaviors generate complex tissue structures during vertebrate development. We focus on the developing mouse embryo as a model to understand how cells coordinate their behaviors in space and time to drive...
Gene expression control is fundamental to all biological systems and is primarily mediated by transcription factors (TFs) that bind specific DNA sequences. This control is quantitative—approximately 50% reductions in TF levels cause rare disorders, while...
The Segel lab is interested in the evolution of mammalian lifespan. From single cells to whole organisms, we are interested in the molecular pathways that govern the pacing of postnatal mammalian development.
The broad interest of the WAGERS LAB is to identify and analyze tissue-specific stem cell populations in adult animals. This work focuses on understanding the factors controlling the migration and expansion of bone marrow-derived and blood-forming...
My laboratory uses a stem cell based approach to understand neurodegenerative diseases, particularly orphan diseases such as Spinal Muscular Atrophy, so that we can identify potentially new therapeutic targets. Our work is based on using disease relevant...
Our lab investigates aging and cancer with an emphasis on nuclear events. Our group discovered that the nucleus of a cell undergoes profound degeneration during aging and tumorigenesis. Our goal is to understand the mechanisms of nuclear degeneration and...
The Camargo Lab is focused on understanding how stem cells build, maintain, and repair tissues, and how these processes go awry in disease. We develop and apply cutting-edge technologies that allow us to study cell fate decisions in their native...
Our lab’s long-term goal is to create a novel gene therapy-based therapeutic to preserve and restore healthy vision for patients suffering from diseases that cause irreversible blindness. In particular, we study a disease called Retinitis Pigmentosa (RP)...
Multicellular organisms are formed by a large number of cell types, which serve as the components of tissues and organs. In the Simoes-Costa Lab, we study how cellular diversity arises during vertebrate embryonic development. We employ systems-level...
