Small cell lung cancer (SCLC) is a highly aggressive and treatment-resistant malignancy with limited therapeutic options. This challenge stems in part from the near-universal loss-of-function (LOF) mutations in key tumor suppressor genes such as RB1 and...
The Horlbeck lab studies Chromatinopathies, a large class of genetic disorders in which disruption of chromatin modifying machinery leads to developmental delay and intellectual disability. The lab seeks to understand how chromatin regulation shapes cell...
The Abudayyeh-Gootenberg lab is focused on the understanding and engineering of programmability in biology. These programmable systems, inspired by natural diversity, provide precise control over genomes, transcriptomes, and cellular identity, and are...
Our group studies patterns of rare genetic variation in large collections of human genomic data, both from patients and reference population individuals, and designs tools and methods to help interpret that variation. We are focused on moving from...
The Gupta Lab studies the gene regulatory networks that cause vascular disease using high-throughput CRISPR screens. We have expanded Perturb-seq methods to cover all 20,000 genes and identified co-regulated gene networks using AI/ML methods. For coronary...
Our research explores how we learn from our mistakes—a fundamental building block of intelligent behavior. As infants learning to walk, we take unsteady steps, fall, adjust, and eventually develop stable locomotion. This iterative cycle of action, error...
We are interested in the fundamental mechanisms of neurodegenerative disorders like Alzheimer’s disease. Over the past century-plus, research has revealed specific proteins that misfold and are deposited in neurodegeneration, and recent discoveries have...
Genomics of human disease. We are interested in the functional consequences of the complete spectrum of genomic variation on human disease, with a particular focus on congenital birth defects, autism, neurodevelopmental disorders, and diverse...
Our laboratory studies molecular control of development and cell differentiation using self-renewing epithelia in the digestive tract as a model system.
The gastrointestinal tract is especially suited for molecular investigation of mechanisms that regulate...
The Robinson lab is based in the Center for Genomic Medicine and Department of Psychiatry at Massachusetts General Hospital, and the Broad Institute of Harvard and MIT. We study genetic influences on human behavioral and cognitive variation, and use...
