The Insco Lab investigates how aberrant RNA and defects in nuclear RNA surveillance drive oncogenesis, with an emphasis on melanoma. We use zebrafish models, patient datasets, and mechanistic assays in human melanoma cell lines to define clinically...
Our laboratory is focused on studying neuroblastoma, an embryonically derived pediatric tumor of the peripheral sympathetic nervous system. We are interested in the following general areas: 1) identifying molecular targets that can be translated into...
The research in our lab focuses on tissue-responsive nanomaterials for biomedical applications and is dedicated to leveraging materials science and engineering, imaging and basic science to improve human health. We develop smart material platforms that...
Pathologists have observed alterations of nuclear structure for over a century. These morphologic nuclear changes are routinely used in cancer diagnostics, however the molecular underpinnings of these changes remain largely unknown. The Johnstone lab is...
The overall goal of the Sethi lab is to combine clinical observations and patient-derived data with rigorous basic science investigation to yield opportunities for impactful translational advances. Our passion for investigative research is fundamentally...
We study the relationships between mammalian double strand break (DSB) repair, genomic instability and cancer. Two major pathways contribute to DSB repair: homologous recombination (HR) and non-homologous end joining (NHEJ). Each plays a key role in...
My laboratory uses a stem cell based approach to understand neurodegenerative diseases, particularly orphan diseases such as Spinal Muscular Atrophy, so that we can identify potentially new therapeutic targets. Our work is based on using disease relevant...
Research in the Roberts laboratory is centered on kinases, kinase inhibitors, and cancer. We work in a variety of model systems and utilize approaches varying from systems biology to mouse genetics. For instance, we have adapted telomerase immortalized...
The focus of my research is to understand mechanisms of sensitivity and resistance to kinase inhibitors and to translate laboratory based observations into therapeutic treatments for patients with cancer. To achieve this goal we have taken a multifaceted...
The overall goal of our research is to understand the role of the tumor microenvironment, including the tumor vasculature and matrix, in tumor growth and response to therapy, to develop novel strategies to manipulate the tumor microenvironment, and to...
