Title: Using protein engineering, antibody evolution and small-molecule discovery to dissect host-pathogen interactions
Key words: Protein engineering, viral evolution, host-pathogen interactions, small-molecule discovery
Our research focuses on the...
My laboratory employs approaches rooted in synthetic immunology as a means of engineering or enhancing the natural immune system with the goal of understanding, preventing and treating HIV infection. We are currently applying these approaches to a number...
My lab studies the interplay between the gut microbiome and the immune system and how their “miscues” can lead to autoimmune diseases, particularly type 1 diabetes. As a 2013 BBS grad, I understand what it takes to have a successful Ph.D. experience.
The...
Work in the Barczak lab focuses on the molecular pathogenesis of Mycobacterium tuberculosis. After COVID-19, tuberculosis is the leading cause of death from infection globally. A comprehensive understanding of the cellular and molecular events that drive...
Protein-based heredity in bacteria. With a primary emphasis on bacterial genetics, our laboratory uses bacteria to study prions and protein-based heredity. Prions are infectious, self-propagating protein aggregates (typically amyloid) that are notorious...
The major interest of the Sharpe laboratory is to study functions of T cell costimulatory pathways and their immunoregulatory roles in controlling the balance between T cell activation and tolerance. Costimulation is of therapeutic interest because...
We study how Epstein-Barr virus causes nearly 1% of all human cancers and also serves as the major viral trigger for autoimmune diseases, in particular multiple sclerosis.
A fascinating and incompletely understood aspect of EBV pathogenesis is that it...
Bacterial pathogens that grow within human cells are responsible for multiple diseases and millions of deaths worldwide. The primary goal of our research is to elucidate both the pathogen and host cell-specific mechanisms involved in the growth, spread...
Our laboratory studies the mechanisms of epigenetic regulation of DNA virus infection. We are interested in the mechanisms by which human cells sense foreign DNA in the cell nucleus and activate transcription of innate response genes and epigenetically...
Work in the Rudner lab focuses on fundamental questions in bacterial cell biology and development: How do bacteria enter and exit dormancy? How are replicated chromosomes organized and segregated? How is the cell envelope remodeled during growth and...
