We are trying to understand how circulating cells manage to leave the blood stream and home to distinct organs or tissues where they may have crucial physiologic functions or may cause disease. Despite considerable progress in this field, it is still...
Research in our lab uses a combination of cellular and molecular approaches in the analysis of T-cell responses to bacterial pathogens. Many virulence factors have been identified which allow bacteria to survive and replicate within the mammalian host...
My research focuses on understanding the relationship between genotype and phenotype, with a special interest in how biochemistry, molecular design, and wiring can allow cells to process information from their environment and respond appropriately. By...
Work in the Rudner lab focuses on fundamental questions in bacterial cell biology and development: How do bacteria enter and exit dormancy? How are replicated chromosomes organized and segregated? How is the cell envelope remodeled during growth and...
Despite years of research, tuberculosis remains a leading killer, causing almost two million deaths each year worldwide. While the treatment for drug-sensitive disease is effective, it requires supervised therapy for extended periods of time and remains...
Despite the growing recognition of the importance of the microbiota to humans, there are fundamental aspects of the microbiota and its relation to the host that are largely unexplored. These range from knowledge of the basic biology of individual strains...
Tissue Immune Regulation
The successful immune response is designed to cope with tissue malfunction or infection and is self-limiting in nature. Immune cells may exert a broad spectrum of context-dependent immune responses in a highly flexible manner...
in situ single-cell transcriptomic techniques offer the exciting ability to characterize gene expression within single cells in their native tissue context. With these technologies, it is possible to discover different types and states of cells in...
We are working to understand how cells respond to pathogens, and how these signaling pathways can be harnessed for new potential therapies to treat cancer and autoimmune diseases. Importantly, many critical aspects of the cellular response to infection...
My lab studies the interplay between the gut microbiome and the immune system and how their “miscues” can lead to autoimmune diseases, particularly type 1 diabetes. As a 2013 BBS grad, I understand what it takes to have a successful Ph.D. experience.
The...
