The Hacohen lab consists of immunologists, geneticists, biochemists, technologists, physicians and computational biologists working together to develop new and unbiased technologies and strategies to understand basic immune processes and immune-mediated...
Our goal is to understand the role of neural-immune interactions in pain, host defense, and immunity. It is increasingly clear that microbes and immune cells release mediators that impact the health and function of the nervous system. Neurons also release...
The Lemieux laboratory investigates the pathogenesis and epidemiology tick-borne and respiratory pathogens using computational and experimental methods. Our primary focus is defining and characterizing the microbial genetic factors that influence Lyme...
The Bhattacharyya lab focuses on characterizing the response of pathogens (bacteria and fungi) to antimicrobials, and of patients to systemic infections, with an emphasis on deepening our mechanistic understanding and diagnosis of infections. While we use...
Work in the Barczak lab focuses on the molecular pathogenesis of Mycobacterium tuberculosis. After COVID-19, tuberculosis is the leading cause of death from infection globally. A comprehensive understanding of the cellular and molecular events that drive...
Question
How can we measure the structures of RNAs in the cell? How does RNA regulate gene expression in normal cells, and what aspects go awry in the onset of disease states such as viral infections, neurodegeneration and cancer?
Approach
RNA viruses have...
The overarching goal of the Jost lab is to define the molecular mechanisms of host-microbiome communication using a combination of systematic CRISPR technologies, physiological cell models such as organoids, and an interdisciplinary set of targeted...
Malaria remains a major public health threat with more than 225 million people infected worldwide and one fourth of the world's population is at risk for infection. More than a million children die from malaria each year, most of them in Africa. Drug...
Research in the Walker laboratory falls into two major areas. One is primarily directed towards addressing the problem of antibiotic resistance. We investigate bacterial pathways that may be targets for new antibiotics. We carry out detailed mechanistic...
We are exploring pathogen-host interactions, particularly in the context of animal models relevant to human infection of clinically important enteric pathogens including Vibrio cholerae, Vibrio parahaemolyticus and enterohemorrhagic Escherichia coli (EHEC...
