BBS Faculty

Our lab aims to understand the in vivo functions of certain genes identified in neurodegenerative and developmental disorders of the human brain such as schizophrenia, Alzheimer's disease, lissencephaly, autism and mental retardation. We use a variety of...

Our research is focused on the nature of highly aggressive, metastatic, late-stage cancers. We believe that such tumors differ markedly from less aggressive tumors and respond to different drugs than either primary tumors or dormant metastases...

The Zhang lab is interested in how epigenetic modification-mediated dynamic changes in chromatin structure affects gene expression, stem cell reprogramming, germ cell development, beta-cell generation, and drug addiction. In the past decade, the lab has...

We are interested in how kinases in general, and phosphatidylinositol 3-kinases (PI3K) in particular, control malignant transformation. The work of our laboratory integrates molecular biology, tissue engineering and novel mouse models of human cancer to...

Our research will integrate organic chemistry, chemical biology, and cancer biology to develop covalent compounds that allow chemical rescue of somatic mutations in cancer currently deemed “undruggable”. Somatic mutations, particularly in proto-oncogenes...

The cell surface is a central hub of biological processes, transducing information from the cell’s surroundings to enable dynamic and specific responses to their local environment. Myriad human diseases result from the dysregulation of extracellular and...

The laboratory focuses on the developmental biology of hematopoiesis and cancer. We have collected over 30 mutants affecting the hematopoietic system. Some of the mutants represent excellent animal models of human disease. We also have undertaken chemical...