The Walt lab pioneered the use of microwell arrays for ultra-sensitive biomarker detection and analysis, such as proteins and microRNAs. The technique, known as Single Molecule Arrays (Simoa), is based on digital enzyme-linked immunosorbent assay (ELISA)...
Our research will integrate organic chemistry, chemical biology, and cancer biology to develop covalent compounds that allow chemical rescue of somatic mutations in cancer currently deemed “undruggable”. Somatic mutations, particularly in proto-oncogenes...
My laboratory uses a stem cell based approach to understand neurodegenerative diseases, particularly orphan diseases such as Spinal Muscular Atrophy, so that we can identify potentially new therapeutic targets. Our work is based on using disease relevant...
Research in the Roberts laboratory is centered on kinases, kinase inhibitors, and cancer. We work in a variety of model systems and utilize approaches varying from systems biology to mouse genetics. For instance, we have adapted telomerase immortalized...
The Rashidian Lab studies cancer immunology and autoimmune disease using expertise in molecular biology, chemical biology and immunology.
The Mekalanos laboratory is engaged in the analysis of bacterial virulence and functional genomics. The goal of these studies is to understand how pathogenic bacteria grow, evade the host immune system and ultimately cause disease. A variety of organisms...
Internal and external senses
We study internal sensory systems using molecular and genetic approaches. The vagus nerve is an essential body-brain communication axis that controls vital functions of the respiratory, cardiovascular, digestive, and immune...
Our laboratory focuses on understanding the role that mitochondria play in mammalian aging and disease. Mitochondria are dynamic organelles that provide cells with energy even during dramatic changes in diet, stress and development. Mitochondria are also...
A major area of our interest is how eukaryotic cells sense and respond to stress in the form of damage to their genetic material. When cells incur DNA damage, they induce the transcription of genes involved in cell cycle arrest and repair of the damage...
The long-term goal of the Devlin lab is to understand and control the chemistry of human-associated bacteria in order to uncover how the microbiome affects human health and disease.
We are not alone. The human body harbors more bacterial cells than human...
