Our laboratory is focused on studying neuroblastoma, an embryonically derived pediatric tumor of the peripheral sympathetic nervous system. We are interested in the following general areas: 1) identifying molecular targets that can be translated into...
The Gredler lab investigates how dynamic cellular behaviors generate complex tissue structures during vertebrate development. We focus on the developing mouse embryo as a model to understand how cells coordinate their behaviors in space and time to drive...
Gene expression control is fundamental to all biological systems and is primarily mediated by transcription factors (TFs) that bind specific DNA sequences. This control is quantitative—approximately 50% reductions in TF levels cause rare disorders, while...
Our lab studies the molecular and cellular basis of novel organismic physiology and behavior. We emphasize curiosity-driven science and exploration, using comparative approaches featuring a range of unusual and specialized organisms that are uniquely...
The Segel lab is interested in the evolution of mammalian lifespan. From single cells to whole organisms, we are interested in the molecular pathways that govern the pacing of postnatal mammalian development.
We are interested in how kinases in general, and phosphatidylinositol 3-kinases (PI3K) in particular, control malignant transformation. The work of our laboratory integrates molecular biology, tissue engineering and novel mouse models of human cancer to...
My laboratory uses genetic, molecular and cellular approaches to investigate critical roles of cell signaling in mammalian embryonic morphogenesis, and homeostatic maintenance of adult tissues, particularly in the skeleton, dental-craniofacial system and...
The broad interest of the WAGERS LAB is to identify and analyze tissue-specific stem cell populations in adult animals. This work focuses on understanding the factors controlling the migration and expansion of bone marrow-derived and blood-forming...
Data generated by the rapidly advancing DNA sequencing technology provide the complete picture of population genetic variation and sequence divergence between species. We have been focused on the analysis of systematic re-sequencing datasets with the goal...
The overall theme of our lab is the regulation of energy homeostasis in mammalian systems, with special reference to adipose and muscle tissues. While we have long been interested in diabetes and obesity, our current interests extend to muscle disorders...
