The van Opijnen Lab works at the intersection of microbial systems biology, functional genomics, and computational modeling. Our central focus is understanding how bacterial pathogens survive the combined assault of host immunity and antibiotic treatment...
We study how Epstein-Barr virus causes nearly 1% of all human cancers and also serves as the major viral trigger for autoimmune diseases, in particular multiple sclerosis.
A fascinating and incompletely understood aspect of EBV pathogenesis is that it...
My lab works at the intersection of virology, immunology and systems biology. Our core mission is to uncover global principles in virology by decoding hundreds of viral genomes. Our projects revolve around a central question: how have the compact genomes...
Our laboratory pursues both basic and translational studies to understand and treat infections caused by intestinal bacteria. Areas of interest described below include the impact of intestinal pathogens on host metabolism and nutrition, development of...
The major interest of the Sharpe laboratory is to study functions of T cell costimulatory pathways and their immunoregulatory roles in controlling the balance between T cell activation and tolerance. Costimulation is of therapeutic interest because...
The Mekalanos laboratory is engaged in the analysis of bacterial virulence and functional genomics. The goal of these studies is to understand how pathogenic bacteria grow, evade the host immune system and ultimately cause disease. A variety of organisms...
The research efforts in the laboratory are directed towards understanding the molecular basis of pathogenesis of human infections caused by opportunistic gram-negative bacteria. We have used Pseudomonas aeruginosa as a model opportunistic pathogen...
My research program focuses on studying mRNA translation in parasites that significantly burden global health, including Leishmania, Babesia, and Plasmodium organisms.
Our efforts notably center on characterizing translation initiation factors and...
Resistance to antibiotics is arguably one of the most important challenges facing human health in the coming decades. It can arise through the acquisition of new genes or through mutations in existing genes that block antimicrobial action. Resistance is...
A major area of our interest is how eukaryotic cells sense and respond to stress in the form of damage to their genetic material. When cells incur DNA damage, they induce the transcription of genes involved in cell cycle arrest and repair of the damage...
